Hepatic sequestration in sickle cell anemia.

Hepatic sequestration in sickle cell anemia.

INTRODUCTION Sickle cell anemia is a chronic debilitating disease affecting a significant portion of patients of African American origin. These patients present to the physicians with myriad of life threatening complications like acute chest syndrome, septic shock, decompensated congestive heart failure secondary to severe pulmonary hypertension, stroke, and multi-organ failure. However, there ...

کم خونی داسی شکل sickle cell anemia

چکیده ندارد.

Hepatic sequestration in sickle cell anaemia.

Several episodes of acute hepatic enlargement associated with a dramatic fall in haemoglobin concentration were observed in two patients with sickle cell anaemia. No appreciable disturbances of liver function or signs of cardiac failure were evident. The most likely mechanism was sequestration of sickled erythrocytes in the liver. This complication, which may have a basis similar to that of spl...

Side Effects of Hydroxyurea in Patients with Sickle Cell Anemia

Background: Hemoglobin S arises is the result of a point mutation (A-T) in the sixth codon on the -globin gene on chromosome 11 causing sickle cell anemia. The presence of fetal hemoglobin in infancy plays a relatively protective role for vaso-occlusive symptoms that are the major contributor for the morbidity and mortality among patients with sickle cell anemia. hydroxyurea, an s-phase-specif...

Sickle cell anemia.